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and is located 15.7 km (9.8 mi) north-west of the international border with Honduras.

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The site was occupied by 200, construction on the acropolis had begun by about 550, and an explosion of grander construction started in the 8th century. Quiriguá shares its architectural and sculptural styles with the nearby Classic Period city of Copán, with whose history it is closely entwined.

All construction had halted by about 850, except for a brief period of reoccupation in the Early Postclassic (c. Quiriguá's rapid expansion in the 8th century was tied to king K'ak' Tiliw Chan Yopaat's military victory over Copán in 738.

Data from uncontrolled, retrospective reviews have suggested that resection of the uterine septum increases delivery rates, although a prospective, controlled trial did not show that surgical correction of uterine abnormalities benefits pregnancy outcomes.

Approximately 10% of human malformations result from environmental causes.

At least 50% of all first-trimester spontaneous abortions (SABs) are cytogenetically abnormal.

For couples who have had an SAB due to a suspected genetic cause, the standard of care is to offer genetic counseling.

A period of eighty years of control from Belgrade followed during which Nikola I died in exile in France in 1921 followed shortly afterwards by the surprise abdication of his son and heir, Danilo III, the same year.

The latter's nephew, Michael Petrović-Njegoš, inherited the titles of his predecessors whilst in exile in France and survived arrest and internment by order of Adolf Hitler for refusing to head up a puppet Montenegrin state aligned to the Axis Powers.

Tests for antiphospholipid antibodies (APLAs), signaling the presence of the autoimmune disease antiphospholipid antibody syndrome (APS), have reportedly been positive in 10-20% of women with early pregnancy losses.

Three classes of clinically significant APL antibodies have been identified: anticardiolipin (a CL), lupus anticoagulant (LAC), and anti-β2 glycoprotein I antibodies.

Montenegro had enjoyed de facto independence from the Ottoman Empire from 1711 but only received formal international recognition as an independent principality in 1878.